After a meteor crash-lands in Colepepper Zoo, it releases a virus that turns all the zoo animals into mindless zombies. A young wolf named Gracie (Gabbi Kosmidis), who has spent her entire life inside the zoo, must team up with a mountain lion named Dan (David Harbour), who is brand new to life in captivity.

Along the way, the pair meet a small group of survivors: Felix the egotistical monkey (Paul Sun-Hyung Lee), Ash the skeptical ostrich (Scott Thompson), Xavier the movie-obsessed lemur (Pierre Simpson), and Frida the fiery capybara (Heather Loreto).

Working as a team, they must find a way to survive the zombie horde and stop the virus to save the zoo.